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Women often use it tell what bosses, husbands and even strangers are thinking and planning. And any number of things can turn them back on. Progesterone increases fold in the first eight weeks of pregnancy, causing most women to become very sedated, Brizendine said. The female brain is not only more responsive to small amounts of stress but is less able to habituate to high levels of stress, said Debra Bangasser of the Children's Hospital of Philadelphia, describing her recent research looking at molecular changes in the brain. It starts around age 43 and reaches its pinnacle by 47 or 48 years old. For females in particular, a negative response may be better than no response at all. While men start to show increased interest in relationships as they age, the mature woman becomes ready to risk conflict — especially if her nest is now empty.

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One way Mother Nature tries to help is through breastfeeding.

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10 Things Every Man Should Know about a Woman's Brain

In addition to erratic periods and night sweats, a woman's hormones during this transition are so crazed she can be as moody as a teenager. For females in particular, a negative response may be better than no response at all. Women may have evolved to avoid physical aggression because of the greater dependence of children on their survival, suggests Anne Campbell of Durham University.

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